Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320365 | 0.91 | HDAC1 (0.78) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL8326475 | 0.88 | HDAC1 (0.79) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL8324002 | 0.81 | HDAC1 (0.59) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL8319740 | 0.79 | HDAC1 (0.51) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL8318738 | 0.74 | HDAC1 (0.49) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL8322744 | 0.73 | HDAC1 (0.52) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL28357772 | 0.72 | KDM4E (0.63) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL28357770 | 0.72 | KDM4E (0.63) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL414598 | 0.72 | HDAC2 (0.67) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL414597 | 0.72 | HDAC2 (0.67) | HDAC1HDAC6HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |