Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16472455 | 0.85 | ALDH1A1 (0.57) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL12683458 | 0.85 | ALDH1A1 (0.57) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10517488 | 0.85 | ALDH1A1 (0.57) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3649936 | 0.85 | POLB (0.51) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3649934 | 0.85 | POLB (0.51) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL30497646 | 0.85 | POLB (0.51) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL20912047 | 0.84 | POLB (0.56) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1404236 | 0.84 | POLB (0.50) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL31554318 | 0.84 | POLB (0.50) | POLBMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8324568 | 0.84 | POLB (0.50) | POLBMEN1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048383-A1 | MIXED LINEAGE KINASE MODULATORS | ELI LILLY AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |