Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12914769 | 0.91 | PDE4B (0.42) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4599962 | 0.90 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL29812927 | 0.90 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL30089091 | 0.89 | POLB (0.48) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL2125428 | 0.89 | POLB (0.48) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL30678922 | 0.87 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL11130440 | 0.87 | LMNA (0.48) | POLBSMN1; SMN2LMNAMAPTGBA2 | |
| SCHEMBL4509104 | 0.86 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8800263 | 0.86 | POLB (0.46) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8800068 | 0.86 | POLB (0.46) | POLBSMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048383-A1 | MIXED LINEAGE KINASE MODULATORS | ELI LILLY AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |