Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 4/20 | 0.44 |
| ▸ | RXRB | P28702 | 3/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324662 | 1.00 | MRGPRX4 (0.49) | MRGPRX4KMT2APTGER1PTGER4PTGER2 | |
| SCHEMBL8675466 | 0.84 | PTGER4 (0.46) | MRGPRX4PTGER1PTGER4PTGER2PTGER3 | |
| SCHEMBL8328295 | 0.84 | MRGPRX4 (0.57) | MRGPRX4KMT2APTGER1PTGER4PTGER2 | |
| SCHEMBL8327587 | 0.84 | RXRA (0.49) | KMT2APTGER1PTGER4PTGER2NR4A1 | |
| SCHEMBL8327584 | 0.84 | RXRA (0.49) | KMT2APTGER1PTGER4PTGER2NR4A1 | |
| SCHEMBL8328293 | 0.84 | MRGPRX4 (0.57) | MRGPRX4KMT2APTGER1PTGER4PTGER2 | |
| SCHEMBL8325865 | 0.82 | MRGPRX4 (0.48) | MRGPRX4KMT2APTGER1PTGER4PTGER2 | |
| SCHEMBL8325869 | 0.82 | MRGPRX4 (0.48) | MRGPRX4KMT2APTGER1PTGER4PTGER2 | |
| SCHEMBL8675468 | 0.81 | MRGPRX4 (0.47) | MRGPRX4KMT2APTGER1PTGER4PTGER2 | |
| SCHEMBL6072389 | 0.81 | PTGER4 (0.62) | MRGPRX4PTGER1PTGER4PTGER2PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |