Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058953 | 0.88 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL8207584 | 0.87 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CCA9 | |
| SCHEMBL8207586 | 0.87 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CCA9 | |
| SCHEMBL8328206 | 0.85 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL5067984 | 0.83 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL5036837 | 0.80 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CCA9 | |
| SCHEMBL5036841 | 0.80 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CCA9 | |
| SCHEMBL2888388 | 0.80 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL2888383 | 0.80 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL2888386 | 0.80 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |