Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 12/20 | 0.48 |
| ▸ | CA1 | P00915 | 8/20 | 0.48 |
| ▸ | CA9 | Q16790 | 6/20 | 0.48 |
| ▸ | CA7 | P43166 | 6/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207584 | 1.00 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CCA2 | |
| SCHEMBL8212946 | 0.93 | CA2 (0.54) | PDE4DPDE4APDE4BPDE4CCA2 | |
| SCHEMBL8212941 | 0.93 | CA2 (0.54) | PDE4DPDE4APDE4BPDE4CCA2 | |
| SCHEMBL8212942 | 0.93 | CA2 (0.54) | PDE4DPDE4APDE4BPDE4CCA2 | |
| SCHEMBL8324856 | 0.87 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CCA2 | |
| SCHEMBL5036837 | 0.84 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CCA2 | |
| SCHEMBL5036841 | 0.84 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CCA2 | |
| SCHEMBL8328206 | 0.84 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2888386 | 0.83 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2888383 | 0.83 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121279-A | PHOSPHODIESTERASE INHIBITOR FOR TREATING RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-09-19 | — | — | US | disclosed |