Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324856 | 0.85 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL8207586 | 0.84 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8207584 | 0.84 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL5058869 | 0.83 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL9319384 | 0.82 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL7390950 | 0.82 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL7704344 | 0.78 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL7704337 | 0.78 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL7704339 | 0.78 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL5036837 | 0.78 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |