Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8329391 | 0.85 | RXFP1 (0.40) | KMT2AMEN1CTSDGUSBHTR2C | |
| SCHEMBL8324947 | 0.85 | CTSD (0.43) | KMT2AMEN1KCNH2CTSDGUSB | |
| SCHEMBL9380965 | 0.82 | CTSD (0.36) | KMT2AMEN1KCNH2CTSDGUSB | |
| Hydrochloric Acid SCHEMBL8328815 | 0.81 | CTSD (0.35) | KMT2AMEN1KCNH2CTSDGUSB | |
| SCHEMBL8321774 | 0.81 | MGAM (0.40) | KMT2AMEN1KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL8328344 | 0.78 | KMT2A (0.39) | KMT2AMEN1KDM4ELMNAALDH1A1 | |
| SCHEMBL8328844 | 0.75 | MGAM (0.39) | KMT2AMEN1KDM4ELMNAGAA | |
| Bromide SCHEMBL8329364 | 0.74 | KDM4E (0.37) | KDM4EALDH1A1MAPTRAB9AL3MBTL1 | |
| SCHEMBL9380971 | 0.72 | KMT2A (0.34) | KMT2AMEN1KCNH2CTSDGUSB | |
| Bromide SCHEMBL8327518 | 0.72 | MEN1 (0.38) | KMT2AMEN1LMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |