⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512273 | 0.73 | — | — | |
| SCHEMBL8475360 | 0.73 | KDM4E (0.33) | — | |
| SCHEMBL20487138 | 0.73 | KDM4E (0.33) | — | |
| SCHEMBL8475356 | 0.73 | KDM4E (0.33) | — | |
| SCHEMBL11261334 | 0.67 | MEN1 (0.37) | — | |
| SCHEMBL2828365 | 0.65 | — | — | |
| SCHEMBL19348056 | 0.65 | — | — | |
| SCHEMBL9595338 | 0.65 | MAPT (0.40) | — | |
| SCHEMBL666310 | 0.65 | — | — | |
| SCHEMBL58395 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674631-B1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER (US) | 1999-12-08 | — | — | EP | disclosed |
| EP-0959074-A2 | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5968944-A | TREATING STRESS AND ANXIETY RELATED DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5958948-A | CORTICOTROPIN RELEASING FACTOR; THERAPY FOR STRESS | PFIZER, INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5705646-A | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0764153-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995033727-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1995-12-14 | — | — | WO | disclosed |
| EP-0674631-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013661-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |