Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | TXN | P10599 | 1/20 | 0.30 |
| ▸ | TYMP | P19971 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6189267 | 0.84 | CYP1A2 (0.33) | — | |
| SCHEMBL5121595 | 0.81 | NOTUM (0.33) | — | |
| SCHEMBL4658503 | 0.79 | MAOB (0.32) | NPC1RAB9AMAOB | |
| SCHEMBL6391148 | 0.78 | — | — | |
| SCHEMBL9559536 | 0.78 | MAOB (0.31) | NPC1RAB9AMAOBTYMP | |
| SCHEMBL9648530 | 0.77 | KCNH2 (0.33) | — | |
| SCHEMBL9436695 | 0.77 | METAP2 (0.30) | — | |
| SCHEMBL11095391 | 0.76 | NPC1 (0.32) | NPC1TP53TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL150096 | 0.75 | MAOB (0.32) | NPC1RAB9AMAOB | |
| SCHEMBL17514582 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |