Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319267 | 0.86 | HDAC6 (0.55) | CYP11B1CYP11B2CYP19A1HDAC6HDAC3 | |
| SCHEMBL7995117 | 0.85 | CYP11B1 (0.52) | CYP11B1CYP11B2CA12CA1CA2 | |
| SCHEMBL7995116 | 0.85 | CYP11B1 (0.52) | CYP11B1CYP11B2CA12CA1CA2 | |
| SCHEMBL21334813 | 0.77 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1HDAC6HDAC3 | |
| SCHEMBL9641646 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2KDM4EHDAC1HDAC8 | |
| SCHEMBL11107722 | 0.76 | TBXAS1 (0.72) | CYP11B1CYP11B2CYP19A1CYP1A2KMT2A | |
| SCHEMBL11107726 | 0.76 | TBXAS1 (0.72) | CYP11B1CYP11B2CYP19A1CYP1A2KMT2A | |
| SCHEMBL8324714 | 0.75 | CA12 (0.48) | CA12CA1CA2TYRCA7 | |
| SCHEMBL28052073 | 0.75 | TBXAS1 (0.70) | CYP11B1CYP11B2CYP19A1CYP1A2KMT2A | |
| SCHEMBL8319380 | 0.74 | HDAC6 (0.46) | CYP11B1CYP11B2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |