Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324964 | 0.81 | KDM4E (0.38) | AOC3MEN1KMT2AKDM4EHDAC4 | |
| SCHEMBL8330722 | 0.81 | IDO1 (0.46) | AOC3SLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL8326960 | 0.80 | TACR1 (0.38) | AOC3MEN1KMT2AKDM4E | |
| SCHEMBL683672 | 0.77 | IDO1 (0.49) | AOC3SLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL8328722 | 0.77 | IDO1 (0.42) | AOC3SLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL16226553 | 0.72 | SLC6A2 (0.50) | AOC3SLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL18526699 | 0.71 | ACHE (0.47) | AOC3SLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL28597604 | 0.70 | ACHE (0.44) | AOC3SLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL10442326 | 0.70 | AOC3 (0.46) | AOC3SLC6A4IDO1TDO2HDAC4 | |
| SCHEMBL16950984 | 0.69 | AOC3 (0.50) | AOC3IDO1TDO2KDM4EHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |