Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 8/20 | 0.67 |
| ▸ | GNAI3 | P08754 | 7/20 | 0.67 |
| ▸ | GNAI1 | P63096 | 7/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | GUSB | P08236 | 2/20 | 0.46 |
| ▸ | EBP | Q15125 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322298 | 1.00 | GNAO1 (0.67) | GNAO1GNAI3GNAI1KCNH2GUSB | |
| SCHEMBL8323545 | 1.00 | GNAO1 (0.67) | GNAO1GNAI3GNAI1KCNH2GUSB | |
| SCHEMBL8321108 | 1.00 | GNAO1 (0.67) | GNAO1GNAI3GNAI1KCNH2GUSB | |
| SCHEMBL8318615 | 1.00 | GNAO1 (0.67) | GNAO1GNAI3GNAI1KCNH2GUSB | |
| SCHEMBL8322736 | 1.00 | GNAO1 (0.67) | GNAO1GNAI3GNAI1KCNH2GUSB | |
| SCHEMBL8324108 | 1.00 | GNAO1 (0.67) | GNAO1GNAI3GNAI1KCNH2GUSB | |
| SCHEMBL8323260 | 0.98 | GNAO1 (0.63) | GNAO1GNAI3GNAI1KCNH2GUSB | |
| SCHEMBL3016331 | 0.91 | GNAO1 (0.55) | GNAO1GNAI3GNAI1KCNH2 | |
| SCHEMBL8324635 | 0.82 | DRD2 (0.47) | GNAO1GNAI3GNAI1 | |
| SCHEMBL19040042 | 0.82 | GNAO1 (0.96) | GNAO1GNAI3GNAI1KCNH2GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| CN-1040436-C | Pharmaceuticals | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | CN | disclosed |