Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1717566 | 0.89 | MMP8 (0.51) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL27816341 | 0.83 | MMP8 (0.51) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL1275691 | 0.81 | MMP8 (0.70) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL27904713 | 0.81 | TSHR (0.49) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL16795580 | 0.81 | MMP8 (0.49) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL2597760 | 0.81 | TSHR (0.49) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL28260519 | 0.81 | MMP8 (0.49) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL27491359 | 0.81 | MMP8 (0.53) | MMP8TSHRKMT2AMEN1NPC1 | |
| SCHEMBL8325798 | 0.80 | ALDH1A1 (0.54) | MMP8TSHRKMT2AALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL10677191 | 0.80 | MMP8 (0.68) | MMP8TSHRKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555327-B1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PROD (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0553263-B1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PROD (US) | 1998-08-05 | — | — | EP | disclosed |
| EP-0458551-B1 | Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1997-12-03 | — | — | EP | disclosed |
| EP-0519600-B1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PROD (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0618917-B1 | 1'-AMINO-2- (BENZOTHIAZOLYL)METHYL]SPIRO ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PROD (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0618917-A1 | 1'-AMINO-2- (BENZOTHIAZOLYL)METHYL]SPIRO ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS. | AMERICAN HOME PROD (US) | 1994-10-12 | — | — | EP | disclosed |
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0555327-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0553263-A1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1993011126-A1 | 1'-AMINO-2-[(BENZOTHIAZOLYL)METHYL]SPIRO [ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-10 | — | — | WO | disclosed |
| US-5093496-A | Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-03 | — | — | US | disclosed |
| US-5081241-A | Diabetes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-14 | — | — | US | disclosed |
| EP-0458551-A1 | Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |
| EP-0458549-A1 | N-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5068332-A | Antidiabetic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-26 | — | — | US | disclosed |
| US-5045544-A | Preventing or relieving neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |
| US-5037831-A | For treatment of diabetes mellitus associated complication | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-08-06 | — | — | US | disclosed |
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |