Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.60 |
| ▸ | EGFR | P00533 | 5/20 | 0.60 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.50 |
| ▸ | PRKDC | P78527 | 9/20 | 0.50 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.50 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.50 |
| ▸ | HCK | P08631 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318618 | 0.83 | ABL1 (0.72) | ABL1EGFRSRCPIK3CDPIK3CA | |
| SCHEMBL8327348 | 0.80 | PIK3CD (0.67) | ABL1EGFRSRCPIK3CDPIK3CA | |
| SCHEMBL8325830 | 0.74 | MAPT (0.49) | ABL1EGFRSRCPIK3CDPIK3CA | |
| SCHEMBL7495874 | 0.73 | CCNB2 (0.58) | ABL1EGFRMAPTNPSR1ALDH1A1 | |
| SCHEMBL6689658 | 0.73 | EGFR (0.70) | ABL1EGFRSRCPIK3CDPIK3CA | |
| SCHEMBL9046890 | 0.71 | ALDH1A1 (0.56) | KDRMAPTNPSR1DYRK1AALDH1A1 | |
| SCHEMBL2257351 | 0.69 | MAPT (0.56) | KDRMAPTNPSR1FLT3DYRK1A | |
| SCHEMBL14983462 | 0.68 | ALDH1A1 (0.45) | PIK3CGMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL8322473 | 0.67 | ABL1 (0.40) | ABL1EGFRSRCPIK3CDPIK3CA | |
| SCHEMBL5647677 | 0.66 | ALDH1A1 (0.50) | ABL1EGFRSRCPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0682519-A4 | ADENOSINE KINASE INHIBITORS. | GENSIA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0682519-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994017803-A9 | ADENOSINE KINASE INHIBITORS | — | 1994-09-29 | — | — | WO | disclosed |
| WO-1994017803-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | disclosed |