Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.70 |
| ▸ | ABL1 | P00519 | 8/20 | 0.70 |
| ▸ | CDK1 | P06493 | 7/20 | 0.61 |
| ▸ | PRKCA | P17252 | 6/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 6/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.50 |
| ▸ | PRKDC | P78527 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235341 | 0.87 | EGFR (0.77) | EGFRABL1CDK1PRKCAPDGFRB | |
| SCHEMBL6689654 | 0.80 | FGFR1 (0.57) | EGFRABL1CDK1PRKCAPDGFRB | |
| SCHEMBL6686760 | 0.79 | EGFR (0.76) | EGFRABL1CDK1PRKCAPDGFRB | |
| SCHEMBL9820168 | 0.77 | DYRK1A (0.57) | CDK1PDGFRBFGFR1DYRK1ADYRK1B | |
| SCHEMBL6684639 | 0.75 | LMNA (0.57) | EGFRABL1CDK1PRKCAPDGFRB | |
| SCHEMBL8325826 | 0.73 | ABL1 (0.60) | EGFRABL1CDK1PRKCAPDGFRB | |
| SCHEMBL31236246 | 0.71 | PDPK1 (0.56) | EGFRCDK1PRKCAPDGFRBPDGFRA | |
| SCHEMBL31236247 | 0.71 | PDPK1 (0.56) | EGFRCDK1PRKCAPDGFRBPDGFRA | |
| SCHEMBL6681340 | 0.69 | FGFR1 (0.57) | EGFRABL1CDK1PRKCAPDGFRB | |
| SCHEMBL4913787 | 0.68 | RAB9A (0.72) | MAPTHTTLMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832092-B1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2004-11-17 | — | — | EP | disclosed |