Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 13/20 | 0.74 |
| ▸ | MMP13 | P45452 | 10/20 | 0.74 |
| ▸ | MMP2 | P08253 | 2/20 | 0.74 |
| ▸ | MMP9 | P14780 | 1/20 | 0.74 |
| ▸ | MMP14 | P50281 | 1/20 | 0.74 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325290 | 0.86 | MMP12 (0.77) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL5613354 | 0.85 | MMP12 (1.00) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL5613400 | 0.85 | MMP12 (0.76) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL5613327 | 0.84 | MMP12 (0.74) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL5613739 | 0.84 | MMP12 (0.74) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL5613445 | 0.81 | MMP12 (1.00) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL12646502 | 0.80 | FFAR1 (0.69) | MMP12MMEMAOAMCL1CYP17A1 | |
| SCHEMBL5613749 | 0.80 | MMP12 (0.67) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL5613741 | 0.79 | MMP12 (0.65) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL5613401 | 0.78 | MMP12 (0.79) | MMP12MMP13MMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654213-B1 | MATRIX METALLOPROTEINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2004110974-A1 | MATRIX METALLOPROTEINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |