Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DDO | Q99489 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15456304 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4EHCAR2MEN1KMT2A | |
| SCHEMBL31015916 | 0.78 | KDM4E (0.68) | ALDH1A1KDM4EHCAR2MEN1KMT2A | |
| SCHEMBL185842 | 0.78 | KDM4E (0.68) | ALDH1A1KDM4EHCAR2MEN1KMT2A | |
| SCHEMBL23021001 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4EHCAR2MEN1KMT2A | |
| SCHEMBL6226308 | 0.76 | CA12 (0.47) | MEN1KMT2APOLBLMNA | |
| SCHEMBL6225141 | 0.76 | HPSE (0.55) | ALDH1A1MEN1KMT2APOLBHTT | |
| SCHEMBL30073943 | 0.76 | HPSE (0.55) | ALDH1A1MEN1KMT2APOLBHTT | |
| Iodide SCHEMBL6773135 | 0.75 | HPSE (0.54) | ALDH1A1MEN1KMT2APOLBHTT | |
| Iodide SCHEMBL6223612 | 0.75 | CA12 (0.46) | MEN1KMT2APOLBLMNA | |
| SCHEMBL22139456 | 0.75 | ALDH1A1 (0.62) | ALDH1A1KDM4EHCAR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738953-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS WITH IMPROVED PHARMACOKINETIC PROPERTIES AND METHODS FOR THEIR MANUFACTURE | Saint Louis University (US) | 2020-11-18 | — | — | EP | disclosed |
| US-20200199079-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS | UNIV SAINT LOUIS (US) | 2020-06-25 | — | — | US | disclosed |
| US-10577330-B2 | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists | SAINT LOUIS UNIVERSITY (US) | 2020-03-03 | — | — | US | disclosed |
| US-20190023663-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS | SAINT LOUIS UNIVERSITY | 2019-01-24 | — | — | US | disclosed |
| US-10035778-B2 | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists | SAINT LOUIS UNIVERSITY (US) | 2018-07-31 | — | — | US | disclosed |
| US-20180072684-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS | SAINT LOUIS UNIVERSITY | 2018-03-15 | — | — | US | disclosed |
| EP-2875021-B1 | BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | UNIV SAINT LOUIS (US) | 2017-08-23 | — | — | EP | disclosed |
| WO-2017117538-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS | SAINT LOUIS UNIVERSITY (US) | 2017-07-06 | — | — | WO | disclosed |
| US-9085606-B2 | Beta amino acid derivatives as integrin antagonists | SAINT LOUIS UNIVERSITY (US) | 2015-07-21 | — | — | US | disclosed |
| WO-2004060376-A1 | THE R-ISOMER OF BETA AMINO ACID COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES | PHARMACIA CORPRATION (US) | 2004-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577330-B2 | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists | ITGA2, ITGAL, ITGA5 | ALDH1A1 877/4885KDM4E 1587/4885HCAR2 122/4885 |
| US-20190023663-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS | ITGA2, ITGAL, ITGA5 | ALDH1A1 877/4885KDM4E 1587/4885HCAR2 122/4885 |
| US-20200199079-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS | ITGA2, ITGAL, ITGA5 | ALDH1A1 877/4885KDM4E 1587/4885HCAR2 122/4885 |
| US-20180072684-A1 | META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS | ITGA2, ITGAL, ITGA5 | ALDH1A1 877/4885KDM4E 1587/4885HCAR2 122/4885 |
| US-10035778-B2 | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists | ITGA2, ITGAL, ITGA5 | ALDH1A1 877/4885KDM4E 1587/4885HCAR2 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.