Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.34 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327513 | 1.00 | HTR2A (0.34) | HTR2AHTR2CEPHX2SIGMAR1NR1H2 | |
| SCHEMBL8653934 | 0.75 | KMT2A (0.46) | EPHX2SIGMAR1DRD2KMT2AL3MBTL1 | |
| SCHEMBL8328030 | 0.73 | HTR2A (0.39) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL6590757 | 0.72 | KCNA3 (0.50) | EPHX2SIGMAR1DRD2KMT2AL3MBTL1 | |
| SCHEMBL8329435 | 0.72 | HTR2A (0.39) | HTR2AHTR2CKMT2A | |
| SCHEMBL8322785 | 0.71 | HTR2A (0.47) | HTR2AHTR2CSIGMAR1KDM1AMAOB | |
| SCHEMBL8328872 | 0.71 | HTR2A (0.47) | HTR2AHTR2CSIGMAR1KDM1AMAOB | |
| SCHEMBL21028327 | 0.71 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1KMT2A | |
| SCHEMBL8322544 | 0.67 | HTR2A (0.40) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL6947042 | 0.67 | PDE4B (0.44) | KMT2AL3MBTL1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |