Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327991 | 0.91 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL8327093 | 0.90 | AGTR1 (0.53) | AGTR1AGTR2PPARG | |
| SCHEMBL11948564 | 0.90 | AGTR1 (0.53) | AGTR1AGTR2PPARG | |
| SCHEMBL8411067 | 0.89 | AGTR1 (0.54) | AGTR1AGTR2CHRM1 | |
| SCHEMBL8327497 | 0.89 | AGTR1 (0.56) | AGTR1AGTR2PPARG | |
| SCHEMBL8323093 | 0.89 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL8325903 | 0.88 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL8327533 | 0.88 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL8324160 | 0.88 | AGTR1 (0.52) | AGTR1AGTR2PPARG | |
| SCHEMBL8327393 | 0.86 | AGTR1 (0.50) | AGTR1AGTR2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498721-B1 | N-substituted quinoline derivatives, process for their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1999-12-22 | — | — | EP | claimed |
| JP-4360872-A | — | — | None | — | — | JP | disclosed |
| US-5985894-A | USEFUL IN THE TREATMENT OF CARDIOVASCULAR ILLNESSES | HOECHST MARION ROUSSEL (FR) | 1999-11-16 | — | — | US | disclosed |
| JP-H04360872-A | NEW N-SUBSTITUTED QUINOLINE DERIVATIVE, ITS PRODUCTION, NEW INTERMEDIATE OBTAINED BY THIS METHOD, ITS USE AS DRUG, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | ROUSSEL UCLAF | 1992-12-14 | — | — | JP | disclosed |