Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 16/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.34 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6261887 | 0.92 | ITGAV (0.39) | ITGAVITGB3ITGB1ITGA5ATM | |
| SCHEMBL8172614 | 0.82 | ITGAV (0.38) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL8039387 | 0.81 | ITGAV (0.40) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL12807108 | 0.81 | KCNH2 (0.42) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL8326050 | 0.79 | ITGAV (0.39) | ITGAVITGB3ATML3MBTL1ITGB6 | |
| SCHEMBL24440037 | 0.79 | ITGAV (0.39) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL2494472 | 0.79 | ITGAV (0.41) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL26538782 | 0.79 | ITGB3 (0.39) | ITGAVITGB3ITGB1ITGA5L3MBTL1 | |
| SCHEMBL5848885 | 0.77 | ITGAV (0.52) | ITGAVITGB3ITGB6ITGB5ITGA2B | |
| SCHEMBL6106216 | 0.76 | ITGB3 (0.52) | ITGAVITGB3ITGB1ITGA5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058254-A1 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |