Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323979 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL8319266 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTSTAT1 | |
| SCHEMBL8324563 | 0.81 | HDAC1 (0.63) | LMNANPC1RAB9AMAPTPOLB | |
| SCHEMBL8325183 | 0.80 | HDAC1 (0.40) | SMN1; SMN2NPC1RAB9AMAPTSTAT1 | |
| SCHEMBL8324583 | 0.80 | KMT2A (0.49) | SMN1; SMN2LMNANPC1RAB9APOLB | |
| SCHEMBL8325372 | 0.79 | HDAC1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTSTAT1 | |
| SCHEMBL5043996 | 0.78 | HDAC1 (0.61) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL8250337 | 0.78 | HDAC1 (0.61) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL8324616 | 0.77 | HDAC1 (0.45) | SMN1; SMN2MAPTPOLBHDAC1HDAC8 | |
| SCHEMBL4258903 | 0.77 | MGLL (0.46) | SMN1; SMN2NPC1RAB9AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |