Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325277 | 1.00 | HTT (0.49) | HTTALDH1A1SMN1; SMN2MAPTPKM | |
| SCHEMBL9057736 | 0.88 | NR4A1 (0.50) | ALDH1A1MAPTKMT2AHPGDMAOB | |
| SCHEMBL7774973 | 0.83 | KMT2A (0.62) | HTTALDH1A1SMN1; SMN2MAPTPKM | |
| SCHEMBL7774977 | 0.83 | KMT2A (0.62) | HTTALDH1A1SMN1; SMN2MAPTPKM | |
| SCHEMBL8324434 | 0.82 | KMT2A (0.55) | HTTALDH1A1SMN1; SMN2MAPTPKM | |
| SCHEMBL8324432 | 0.82 | KMT2A (0.55) | HTTALDH1A1SMN1; SMN2MAPTPKM | |
| SCHEMBL8676414 | 0.77 | KMT2A (0.48) | HTTALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL8328747 | 0.77 | MAPT (0.54) | HTTALDH1A1SMN1; SMN2MAPTPKM | |
| SCHEMBL7777940 | 0.76 | ALDH1A1 (0.49) | HTTALDH1A1MAPTKMT2AMAOB | |
| SCHEMBL8408179 | 0.75 | HDAC1 (0.53) | ALDH1A1SMN1; SMN2MAPTPKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |