Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326381 | 0.88 | HTT (0.49) | PPIAGSK3BBACE1MAOBKMT2A | |
| SCHEMBL8325277 | 0.88 | HTT (0.49) | PPIAGSK3BBACE1MAOBKMT2A | |
| SCHEMBL8318304 | 0.85 | NR4A1 (0.48) | NR4A1NR4A2NR4A3SRD5A2PPIA | |
| SCHEMBL8318302 | 0.85 | NR4A1 (0.48) | NR4A1NR4A2NR4A3SRD5A2PPIA | |
| SCHEMBL7774919 | 0.82 | PTGER1 (0.64) | NR4A1NR4A2NR4A3SRD5A2PTGER1 | |
| SCHEMBL7767009 | 0.78 | NR4A2 (0.81) | NR4A1NR4A2NR4A3SRD5A2ABCG2 | |
| SCHEMBL8676414 | 0.76 | KMT2A (0.48) | PPIAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4035249 | 0.75 | CCNB2 (0.47) | MAOBPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8676412 | 0.75 | PTGER4 (0.47) | PTGER1PTGER4PTGER3PTGER2KDM4E | |
| SCHEMBL8322839 | 0.74 | PTGER4 (0.57) | NR4A1NR4A2NR4A3SRD5A2PPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |