Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.36 |
| ▸ | ANPEP | P15144 | 3/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 3/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324453 | 0.81 | IDO1 (0.44) | IDO1TDO2ERAP1ANPEPERAP2 | |
| SCHEMBL8327831 | 0.74 | METAP2 (0.41) | ERAP1ANPEPERAP2METAP2LAP3 | |
| SCHEMBL8330006 | 0.73 | ERAP1 (0.39) | IDO1TDO2ERAP1ANPEPERAP2 | |
| SCHEMBL8328483 | 0.73 | ERAP1 (0.39) | IDO1TDO2ERAP1ANPEPERAP2 | |
| SCHEMBL8321060 | 0.71 | ERAP1 (0.37) | IDO1TDO2ERAP1ANPEPERAP2 | |
| SCHEMBL8326680 | 0.71 | ERAP1 (0.37) | IDO1TDO2ERAP1ANPEPERAP2 | |
| SCHEMBL8325222 | 0.70 | ERAP1 (0.36) | IDO1TDO2ERAP1ANPEPERAP2 | |
| SCHEMBL5924988 | 0.65 | ANPEP (0.50) | ERAP1ANPEPERAP2HTR2ACYP2A6 | |
| SCHEMBL855071 | 0.65 | ANPEP (0.50) | ERAP1ANPEPERAP2HTR2ACYP2A6 | |
| SCHEMBL6432692 | 0.65 | ANPEP (0.50) | ERAP1ANPEPERAP2HTR2ACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |