Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328576 | 0.87 | AURKA (0.42) | RIPK1AURKAPARP1FEN1NPC1 | |
| SCHEMBL9386690 | 0.81 | KDM4E (0.40) | RIPK1AURKAPARP1FEN1NPC1 | |
| SCHEMBL8329539 | 0.77 | PKM (0.43) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL30324482 | 0.73 | KDM4E (0.50) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL855363 | 0.73 | KDM4E (0.50) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL31405650 | 0.73 | ALDH1A1 (0.59) | ALDH1A1TSHRHTTKMT2AMAPT | |
| SCHEMBL3921386 | 0.71 | HTT (0.39) | RIPK1AURKAPARP1FEN1ALDH1A1 | |
| SCHEMBL21115235 | 0.70 | AURKA (0.46) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL8324581 | 0.70 | AURKA (0.46) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL28329874 | 0.70 | AXL (0.47) | AURKAPARP1FEN1NPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |