Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 9/20 | 0.48 |
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327109 | 1.00 | KCNN4 (0.48) | KCNN4KIF11KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL8321366 | 0.83 | ALDH1A1 (0.58) | KCNN4KIF11ALDH1A1TSHR | |
| SCHEMBL8322782 | 0.83 | ALDH1A1 (0.58) | KCNN4KIF11ALDH1A1TSHR | |
| SCHEMBL8321573 | 0.82 | KIF11 (0.49) | KCNN4KIF11NFE2L2 | |
| SCHEMBL8321948 | 0.82 | KIF11 (0.49) | KCNN4KIF11NFE2L2 | |
| SCHEMBL29001565 | 0.79 | KCNN4 (0.53) | KCNN4KIF11KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL8322052 | 0.79 | KIF11 (0.50) | KCNN4KIF11MEN1LMNAKMT2A | |
| SCHEMBL18435025 | 0.79 | HTT (0.46) | KCNN4KIF11KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL5479948 | 0.78 | KCNN4 (0.70) | KCNN4KIF11KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL8325626 | 0.78 | KCNN4 (0.43) | KCNN4KIF11KCNE1KCNQ1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |