Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326484 | 1.00 | HRH3 (0.41) | HRH3FUCA1GRIN2BDRD2DRD3 | |
| SCHEMBL8326482 | 1.00 | HRH3 (0.41) | HRH3FUCA1GRIN2BDRD2DRD3 | |
| SCHEMBL8326773 | 1.00 | HRH3 (0.41) | HRH3FUCA1GRIN2BDRD2DRD3 | |
| SCHEMBL8325933 | 0.76 | CCKBR (0.40) | KMT2A | |
| SCHEMBL5242542 | 0.75 | FUCA1 (0.64) | HRH3FUCA1GRIN2BDRD2DRD3 | |
| SCHEMBL8321461 | 0.74 | CYP2D6 (0.41) | KMT2AHTR2AHTR2C | |
| SCHEMBL8321466 | 0.74 | CYP2D6 (0.41) | KMT2AHTR2AHTR2C | |
| SCHEMBL8328027 | 0.73 | HTR2A (0.46) | HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL8327629 | 0.71 | HTR2A (0.45) | HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL8327632 | 0.71 | HTR2A (0.45) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |