Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326773 | 0.76 | HRH3 (0.41) | KMT2A | |
| SCHEMBL8326484 | 0.76 | HRH3 (0.41) | KMT2A | |
| SCHEMBL8326482 | 0.76 | HRH3 (0.41) | KMT2A | |
| SCHEMBL8326486 | 0.76 | HRH3 (0.41) | KMT2A | |
| SCHEMBL10262574 | 0.72 | TSHR (0.47) | HPGDTSHRDPP4ALDH1A1MEN1 | |
| SCHEMBL6508105 | 0.68 | ALDH1A1 (0.59) | HPGDTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8328027 | 0.66 | HTR2A (0.46) | SIGMAR1 | |
| SCHEMBL8449826 | 0.66 | MAPT (0.42) | TSHRALDH1A1KMT2AMAPTSIGMAR1 | |
| SCHEMBL8325787 | 0.66 | HTR2A (0.40) | TSHRALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8327629 | 0.65 | HTR2A (0.45) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |