Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.69 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.69 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.69 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.69 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 5/20 | 0.45 |
| ▸ | RXRB | P28702 | 4/20 | 0.45 |
| ▸ | RXRG | P48443 | 3/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322839 | 0.92 | PTGER4 (0.57) | PTGER1PTGER4PTGER3PTGER2NR4A1 | |
| SCHEMBL8678253 | 0.85 | CNR2 (0.48) | PTGER1PTGER4PTGER3PTGER2FOLH1 | |
| SCHEMBL8327583 | 0.83 | PTGER1 (0.62) | PTGER1PTGER4PTGER3PTGER2NR4A1 | |
| SCHEMBL8319420 | 0.82 | PTGER1 (1.00) | PTGER1PTGER4PTGER3PTGER2NR4A1 | |
| SCHEMBL8328747 | 0.81 | MAPT (0.54) | PTGER1PTGER4PTGER3PTGER2PPIA | |
| SCHEMBL8325162 | 0.80 | PTGER1 (0.69) | PTGER1PTGER4PTGER3PTGER2NR4A1 | |
| SCHEMBL8676662 | 0.79 | ALDH1A1 (0.51) | FOLH1POLBTSHRSMN1; SMN2MEN1 | |
| SCHEMBL8321768 | 0.79 | PTGER1 (0.95) | PTGER1PTGER4PTGER3PTGER2NR4A1 | |
| SCHEMBL8678257 | 0.79 | TDP1 (0.50) | PTGER1PTGER4PTGER3PTGER2PPIA | |
| SCHEMBL8327698 | 0.79 | PTGER1 (0.78) | PTGER1PTGER4PTGER3PTGER2PPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |