Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 3/20 | 0.36 |
| ▸ | ATP4B | P51164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014249 | 0.93 | ATP4A (0.40) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL7011597 | 0.78 | ATP4A (0.44) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL7014264 | 0.76 | PLA2G1B (0.42) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL7006186 | 0.75 | PLA2G1B (0.48) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL7006657 | 0.74 | PLA2G1B (0.39) | ATP4AATP4BMAPK14PLA2G1BPTGER1 | |
| SCHEMBL7013631 | 0.74 | ATP4A (0.42) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL7010964 | 0.73 | PLA2G1B (0.47) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL8321751 | 0.73 | L3MBTL1 (0.46) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL7011801 | 0.72 | PLA2G1B (0.45) | ATP4AATP4BMAPK1MEN1CYP1A2 | |
| SCHEMBL7014295 | 0.72 | PLA2G1B (0.49) | ATP4AATP4BMAPK1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |