Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004442 | 0.84 | KDM4E (0.42) | CYP3A4MAPTKDM4ESMN1; SMN2AURKA | |
| SCHEMBL21397179 | 0.83 | HTT (0.44) | MAPTKDM4ESMN1; SMN2AURKAPARP1 | |
| SCHEMBL16496769 | 0.80 | KDM4E (0.42) | CYP3A4MAPTKDM4ESMN1; SMN2AURKA | |
| SCHEMBL1778446 | 0.80 | HTR6 (0.49) | CYP3A4MAPTKDM4ESMN1; SMN2AURKA | |
| SCHEMBL7980631 | 0.79 | KDM4E (0.41) | CYP3A4MAPTKDM4ESMN1; SMN2AURKA | |
| SCHEMBL8326898 | 0.78 | CHEK1 (0.42) | MAPTSMN1; SMN2AURKAPARP1KLK6 | |
| Hydrochloric Acid SCHEMBL21546061 | 0.78 | SMN1; SMN2 (0.49) | CYP3A4SMN1; SMN2AURKAPARP1HTR6 | |
| SCHEMBL8327130 | 0.77 | AURKA (0.44) | MAPTKDM4ESMN1; SMN2AURKAPARP1 | |
| SCHEMBL16464155 | 0.77 | HTR6 (0.51) | KDM4ESMN1; SMN2HTR6ALDH1A1 | |
| SCHEMBL858046 | 0.75 | ALDH1A1 (0.38) | AURKAPARP1KLK6ALDH1A1LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |