Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328187 | 1.00 | PPIA (0.49) | PPIARAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL8322219 | 0.82 | PTGER1 (0.52) | PPIARAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL8322247 | 0.77 | CYP19A1 (0.56) | PPIARAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL8677127 | 0.76 | RAB9A (0.56) | PPIARAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL8327466 | 0.72 | PTGER1 (0.54) | KMT2AKDM4EMAPTPTGER4PTGER3 | |
| SCHEMBL8322906 | 0.72 | PTGER4 (0.47) | KDM4EPTGER4PTGER3PTGER2ALDH1A1 | |
| SCHEMBL8327463 | 0.72 | PTGER1 (0.54) | KMT2AKDM4EMAPTPTGER4PTGER3 | |
| SCHEMBL8322908 | 0.72 | PTGER4 (0.47) | KDM4EPTGER4PTGER3PTGER2ALDH1A1 | |
| SCHEMBL8459732 | 0.71 | PTGER1 (0.66) | RAB9AKMT2AKDM4EMEN1CYP19A1 | |
| SCHEMBL20691188 | 0.70 | KMT2A (0.74) | RAB9AKMT2AKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |