Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | BRD4 | O60885 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | PPIA | P62937 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979237 | 0.81 | GABRA1 (0.49) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8677124 | 0.80 | MEN1 (0.56) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL29954243 | 0.79 | CYP19A1 (0.60) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL4481551 | 0.79 | MEN1 (0.67) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL27675866 | 0.77 | PTPN1 (0.45) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL8328185 | 0.77 | PPIA (0.49) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL8328187 | 0.77 | PPIA (0.49) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9528336 | 0.77 | MRGPRX4 (0.53) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL8459732 | 0.77 | PTGER1 (0.66) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL8677127 | 0.76 | RAB9A (0.56) | CYP19A1CYP11B1CYP11B2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |