SCHEMBL8328255

SCHEMBL8328255

C=CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCN(C)C)c2)c2cccnc21

nearest known ligand 0.70

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ACAT1 P24752 1/20 0.68
SOAT1 P35610 1/20 0.67
USP1 O94782 1/20 0.35
PDE4A P27815 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8326346 0.93 ACAT1 (0.69) ACAT1SOAT1PDE4AKCNH2
SCHEMBL6635594 0.93 ACAT1 (0.76) ACAT1SOAT1PDE4AKCNH2
SCHEMBL8328479 0.92 ACAT1 (0.69) ACAT1SOAT1PDE4AKCNH2
SCHEMBL6635954 0.90 ACAT1 (0.76) ACAT1SOAT1USP1
SCHEMBL8330484 0.90 ACAT1 (0.67) ACAT1SOAT1
SCHEMBL8328556 0.89 ACAT1 (0.67) ACAT1SOAT1
SCHEMBL8327527 0.89 ACAT1 (0.66) ACAT1SOAT1
SCHEMBL8328835 0.89 ACAT1 (0.66) ACAT1SOAT1
SCHEMBL8326825 0.88 ACAT1 (0.63) ACAT1SOAT1
SCHEMBL6634082 0.88 ACAT1 (0.64) ACAT1SOAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0947515-A1 NOVEL NAPHTHYRIDINE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1999-10-06 EP disclosed