Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | AGER | Q15109 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3279880 | 0.89 | KDM4E (0.69) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL5902495 | 0.87 | PARP1 (0.50) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL9130938 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL27780749 | 0.80 | TLR7 (0.46) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL4915812 | 0.78 | P2RX7 (0.66) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL6992077 | 0.78 | SMN1; SMN2 (0.63) | KDM4EALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL20913126 | 0.78 | CTSA (0.47) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL13266784 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL13244599 | 0.78 | P2RX7 (0.71) | KDM4EALDH1A1ALOX15CYP3A4MAPT | |
| SCHEMBL7045677 | 0.78 | HDAC1 (0.46) | KDM4EALDH1A1ALOX15CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001329-A | A TOXIN FUSED TO A TARGETING MOIETY WHICH BINDS TO A RECEPTOR OVEREXPRESSED BY TUMOR CELLS SUCH AS INTERLEUKINS, OR EPIDERMAL GROWTH FACTOR, WHEREIN SAID TOXIN-TARGETING FUSION MOIETY IS LABELED WITH A RADIONUCLIDE | UAB RESEARCH FOUNDATION (US) | 1999-12-14 | — | — | US | disclosed |
| WO-1997042217-A1 | RADIOLABELED FUSION TOXINS FOR CANCER THERAPY | THE UAB RESEARCH FOUNDATION (US) | 1997-11-13 | — | — | WO | disclosed |