SCHEMBL8328829

SCHEMBL8328829

CC(C)c1cccc(C(C)C)c1NC(=O)Nc1c(-c2cccc(OCc3cccnc3)c2)c2cccnc2n(CCc2ccccc2)c1=O

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ACAT1 P24752 1/20 0.58
SOAT1 P35610 1/20 0.57
GPR132 Q9UNW8 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8327121 0.96 ACAT1 (0.61) ACAT1SOAT1GPR132
SCHEMBL8327541 0.94 ACAT1 (0.61) ACAT1SOAT1
SCHEMBL8324509 0.94 ACAT1 (0.59) ACAT1SOAT1
SCHEMBL8329032 0.93 ACAT1 (0.64) ACAT1SOAT1GPR132
SCHEMBL8329270 0.93 ACAT1 (0.56) ACAT1SOAT1GPR132
SCHEMBL8327990 0.92 ACAT1 (0.59) ACAT1SOAT1
SCHEMBL8327420 0.92 ACAT1 (0.68) ACAT1SOAT1GPR132
SCHEMBL5990213 0.92 ACAT1 (0.70) ACAT1SOAT1GPR132
SCHEMBL29427709 0.92 ACAT1 (0.70) ACAT1SOAT1GPR132
SCHEMBL8327777 0.91 ACAT1 (0.61) ACAT1SOAT1GPR132

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0947515-A1 NOVEL NAPHTHYRIDINE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1999-10-06 EP disclosed