Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654624 | 0.93 | GAA (0.45) | SMN1; SMN2HPGDNOD2NOD1MEN1 | |
| SCHEMBL8657547 | 0.84 | ALDH1A1 (0.45) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2017274 | 0.82 | MEN1 (0.51) | MEN1KMT2AKDM4EGAA | |
| SCHEMBL8658440 | 0.78 | KDM4E (0.40) | SMN1; SMN2HPGDNOD2NOD1MEN1 | |
| SCHEMBL8326257 | 0.75 | KDM4E (0.42) | SMN1; SMN2HPGDNOD2NOD1MEN1 | |
| SCHEMBL9430368 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDNOD2NOD1MEN1 | |
| SCHEMBL12320537 | 0.71 | MEN1 (0.50) | MEN1KMT2AKDM4EGAA | |
| SCHEMBL1835860 | 0.68 | KMT2A (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8657539 | 0.68 | ALDH1A1 (0.47) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8655802 | 0.67 | MAPT (0.44) | SMN1; SMN2HPGDNOD2NOD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5721245-A | ANTIINFLAMMATORY AGENTS, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5374727-A | Using rhodium-diphosphine complex as hydrogenation catalyst | HOFFMANN-LA ROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |