Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18202192 | 0.86 | HSD17B10 (0.38) | ALDH1A1KDM4EHPGDHSD17B10CHRM2 | |
| SCHEMBL1614269 | 0.84 | MAPT (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8326257 | 0.83 | KDM4E (0.42) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9256630 | 0.83 | MAPT (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8328796 | 0.81 | NOD2 (0.39) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL8658440 | 0.75 | KDM4E (0.40) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8657539 | 0.74 | ALDH1A1 (0.47) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8447552 | 0.73 | ALDH1A1 (0.44) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9262011 | 0.72 | ALDH1A1 (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8328343 | 0.72 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721245-A | ANTIINFLAMMATORY AGENTS, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |