Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23985093 | 0.83 | TSHR (0.44) | TSHR | |
| SCHEMBL634591 | 0.81 | TSHR (0.36) | TSHRALDH1A1TDP1NLRP3CYP1A2 | |
| SCHEMBL1064223 | 0.77 | TSHR (0.33) | TSHR | |
| SCHEMBL8509214 | 0.77 | TSHR (0.33) | TSHR | |
| SCHEMBL21697444 | 0.74 | TSHR (0.39) | TSHRALDH1A1TDP1NLRP3 | |
| SCHEMBL20386983 | 0.74 | TSHR (0.39) | TSHRALDH1A1TDP1NLRP3CYP1A2 | |
| SCHEMBL4819967 | 0.73 | TSHR (0.30) | TSHR | |
| SCHEMBL14338420 | 0.70 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL6066327 | 0.69 | TSHR (0.30) | TSHR | |
| SCHEMBL9934054 | 0.68 | TSHR (0.33) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864032-A | Phosphoramidite derivatives, their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides | AMERSHAM INTERNATIONAL PLC (GB) | 1999-01-26 | — | — | US | disclosed |
| US-5567811-A | Phosphoramidite derivatives, their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides | AMERSHAM INTERNATIONAL PLC (GB) | 1996-10-22 | — | — | US | disclosed |
| EP-0527184-B1 | PHOSPHORAMIDITE DERIVATIVES, THEIR PREPARATION AND THE USE THEREOF IN THE INCORPORATION OF REPORTER GROUPS ON SYNTHETIC OLIGONUCLEOTIDES | AMERSHAM INT PLC (GB) | 1995-08-02 | — | — | EP | disclosed |
| EP-0527184-A1 | PHOSPHORAMIDITE DERIVATIVES, THEIR PREPARATION AND THE USE THEREOF IN THE INCORPORATION OF REPORTER GROUPS ON SYNTHETIC OLIGONUCLEOTIDES. | AMERSHAM INT PLC (GB) | 1993-02-17 | — | — | EP | disclosed |
| WO-1991017169-A1 | PHOSPHORAMIDITE DERIVATIVES, THEIR PREPARATION AND THE USE THEREOF IN THE INCORPORATION OF REPORTER GROUPS ON SYNTHETIC OLIGONUCLEOTIDES | AMERSHAM INTERNATIONAL PLC (GB) | 1991-11-14 | — | — | WO | disclosed |