Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324694 | 0.86 | MAPT (0.40) | MAPTL3MBTL1RAB9ANPSR1ADORA3 | |
| SCHEMBL8466029 | 0.80 | SCN9A (0.32) | KMT2AMEN1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8466300 | 0.77 | GAA (0.43) | MAPTPOLBSMN1; SMN2GAATDP1 | |
| SCHEMBL8322673 | 0.77 | AURKA (0.36) | KMT2AMEN1POLBSMN1; SMN2GAA | |
| Water SCHEMBL8468351 | 0.77 | NPY5R (0.44) | KMT2AMEN1MAPTMAPK1NPY5R | |
| SCHEMBL8329043 | 0.76 | TEAD1 (0.39) | SMN1; SMN2 | |
| SCHEMBL8326878 | 0.75 | KDM4E (0.41) | KMT2AMEN1MAPTGAATDP1 | |
| SCHEMBL8320446 | 0.75 | NPC1 (0.49) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8462048 | 0.75 | KDM4E (0.39) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8321754 | 0.75 | KDM4E (0.41) | MAPTPOLBSMN1; SMN2GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | claimed |