Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324694 | 0.84 | MAPT (0.40) | — | |
| SCHEMBL8466029 | 0.82 | SCN9A (0.32) | CYP11B2NR3C1SMN1; SMN2 | |
| SCHEMBL8462048 | 0.80 | KDM4E (0.39) | NR3C1SMN1; SMN2 | |
| SCHEMBL8322376 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2 | |
| SCHEMBL8320446 | 0.80 | NPC1 (0.49) | SMN1; SMN2 | |
| SCHEMBL8321754 | 0.80 | KDM4E (0.41) | TP53SMN1; SMN2 | |
| SCHEMBL8322673 | 0.79 | AURKA (0.36) | TRPM8TP53SMN1; SMN2 | |
| SCHEMBL8329140 | 0.76 | KMT2A (0.47) | SMN1; SMN2 | |
| SCHEMBL8466300 | 0.74 | GAA (0.43) | TP53SMN1; SMN2 | |
| SCHEMBL8326878 | 0.73 | KDM4E (0.41) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | claimed |