Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | PMM2 | O15305 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | LHCGR | P22888 | 1/20 | 0.33 |
| ▸ | UQCRB | P14927 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324694 | 0.87 | MAPT (0.40) | MPIPHOSPHO1TRPV1KDM4ERAB9A | |
| SCHEMBL8321754 | 0.85 | KDM4E (0.41) | SMN1; SMN2LMNATP53POLBGAA | |
| SCHEMBL8466029 | 0.85 | SCN9A (0.32) | SMN1; SMN2MEN1KMT2ANPC1LMNA | |
| SCHEMBL8322376 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2ANPC1LMNAGAA | |
| SCHEMBL8462048 | 0.83 | KDM4E (0.39) | SMN1; SMN2MEN1KMT2ANPC1LMNA | |
| SCHEMBL8320446 | 0.83 | NPC1 (0.49) | SMN1; SMN2MEN1KMT2ANPC1LMNA | |
| SCHEMBL8329043 | 0.79 | TEAD1 (0.39) | SMN1; SMN2TP53TRPM8 | |
| SCHEMBL8466300 | 0.77 | GAA (0.43) | SMN1; SMN2NPC1LMNATP53POLB | |
| SCHEMBL8329140 | 0.77 | KMT2A (0.47) | SMN1; SMN2MEN1KMT2ANPC1LMNA | |
| Water SCHEMBL8462183 | 0.76 | SMN1; SMN2 (0.36) | AURKASMN1; SMN2MEN1KMT2APMM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | claimed |
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | disclosed |