Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | IL2 | P60568 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323540 | 0.83 | NOTUM (0.40) | MAOBNOTUMIDO1TSHRMAPK1 | |
| SCHEMBL9539339 | 0.82 | RORB (0.46) | MAOBNOTUMIDO1TSHRMAPK1 | |
| SCHEMBL15949380 | 0.82 | IKBKB (0.41) | MAOBNOTUMIDO1TSHRMAPK1 | |
| SCHEMBL16719324 | 0.82 | CNR2 (0.43) | MAOBNOTUMIDO1TSHRMAPK1 | |
| SCHEMBL11031993 | 0.82 | NOTUM (0.39) | MAOBNOTUMIDO1TSHRMAPK1 | |
| SCHEMBL9648992 | 0.79 | AKR1C3 (0.41) | MAOBNOTUMIDO1AKR1C3AKR1C2 | |
| SCHEMBL10494072 | 0.79 | TAAR1 (0.41) | NOTUMIDO1TAAR1 | |
| SCHEMBL9815443 | 0.78 | KDM4E (0.49) | MAOBNOTUMIDO1TSHRMAPK1 | |
| SCHEMBL8322022 | 0.78 | CYP1A2 (0.42) | NOTUMIDO1AKR1C3AKR1C2HTR2C | |
| SCHEMBL13858635 | 0.78 | NPSR1 (0.45) | AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |