Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GPX4 | P36969 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3021266 | 0.86 | RXRA (0.35) | TSHRCNR2KIF11 | |
| SCHEMBL8329144 | 0.83 | MAOB (0.42) | NOTUMIDO1TSHRMAPK1SCN2A | |
| SCHEMBL2426847 | 0.83 | CYP11B2 (0.43) | NOTUMIDO1MAOB | |
| SCHEMBL16719324 | 0.82 | CNR2 (0.43) | NOTUMIDO1TSHRMAPK1SCN2A | |
| SCHEMBL15949380 | 0.82 | IKBKB (0.41) | NOTUMIDO1TSHRMAPK1SCN2A | |
| SCHEMBL11031993 | 0.82 | NOTUM (0.39) | NOTUMIDO1TSHRMAPK1SCN2A | |
| SCHEMBL9539339 | 0.82 | RORB (0.46) | NOTUMIDO1TSHRMAPK1SCN2A | |
| SCHEMBL3829054 | 0.81 | KIF11 (0.45) | NOTUMTSHRSCN2AMAOBKIF11 | |
| SCHEMBL1369135 | 0.80 | KIF11 (0.39) | IDO1TSHRKIF11POLB | |
| SCHEMBL11287914 | 0.80 | NOTUM (0.43) | NOTUMIDO1TSHRMAPK1SCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |