Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329418 | 0.90 | MAPT (0.57) | MAPTNPC1SMN1; SMN2DYRK1APAX8 | |
| SCHEMBL8329323 | 0.90 | GAA (0.47) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8327531 | 0.89 | MAPT (0.43) | MAPTMELK | |
| Hydrochloric Acid SCHEMBL8326208 | 0.89 | MAPT (0.56) | MAPTNPC1SMN1; SMN2DYRK1APAX8 | |
| Hydrochloric Acid SCHEMBL9050309 | 0.88 | MAPT (0.42) | MAPTSLC2A1MELK | |
| SCHEMBL8329154 | 0.88 | MAPT (0.42) | MAPTKDM4ENPC1SMN1; SMN2POLB | |
| SCHEMBL8328001 | 0.86 | MELK (0.47) | MAPTPOLBKMT2ADYRK1AMELK | |
| SCHEMBL8327738 | 0.84 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2POLBOPRM1 | |
| SCHEMBL8330060 | 0.83 | MAPT (0.39) | MAPTKDM4ENPC1SMN1; SMN2POLB | |
| SCHEMBL8324824 | 0.81 | GAA (0.50) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |