Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8332882 | 1.00 | HTR2A (0.47) | HTR2AHTR2CHTR2BSLC9A1CHRM2 | |
| SCHEMBL8333441 | 0.92 | SLC9A1 (0.39) | HTR2AHTR2CHTR2BSLC9A1CHRM2 | |
| SCHEMBL8333438 | 0.92 | SLC9A1 (0.39) | HTR2AHTR2CHTR2BSLC9A1CHRM2 | |
| SCHEMBL8330683 | 0.90 | HTR2A (0.49) | HTR2AHTR2CHTR2BSLC9A1CHRM2 | |
| SCHEMBL8331305 | 0.87 | HTR2A (0.46) | HTR2AHTR2CHTR2BSLC9A1CHRM2 | |
| SCHEMBL8332123 | 0.86 | HTR2A (0.48) | HTR2AHTR2CHTR2BSLC9A1CHRM2 | |
| SCHEMBL8331359 | 0.84 | HTR2A (0.43) | HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL8331482 | 0.84 | HTR2C (0.43) | HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL8331603 | 0.84 | HTR2A (0.43) | HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL8332789 | 0.83 | SLC9A1 (0.51) | HTR2AHTR2CHTR2BSLC9A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | claimed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |