Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8676947 | 0.90 | HTR1A (0.54) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8327887 | 0.89 | PTGER1 (0.49) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8319651 | 0.88 | CYP11B1 (0.57) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8676954 | 0.88 | HTR1A (0.56) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8322148 | 0.85 | PTGER1 (0.48) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8323432 | 0.85 | PTGER1 (0.57) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8327698 | 0.81 | PTGER1 (0.78) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8322518 | 0.81 | PTGER1 (0.63) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8327425 | 0.79 | PTGER1 (0.61) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8325504 | 0.78 | HTR1A (0.60) | HTR1ADRD2PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |