Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319651 | 0.90 | CYP11B1 (0.57) | PTGER1CYP11B1CYP11B2HTR1ADRD2 | |
| SCHEMBL8327887 | 0.85 | PTGER1 (0.49) | PTGER1CYP11B1CYP11B2HTR1ADRD2 | |
| SCHEMBL8329372 | 0.85 | HTR1A (0.57) | PTGER1CYP11B1CYP11B2HTR1ADRD2 | |
| SCHEMBL8676947 | 0.80 | HTR1A (0.54) | PTGER1CYP11B1CYP11B2HTR1ADRD2 | |
| SCHEMBL8676954 | 0.74 | HTR1A (0.56) | PTGER1HTR1ADRD2LRRK2MEN1 | |
| SCHEMBL8324167 | 0.72 | PTGER1 (0.51) | PTGER1MEN1KMT2APTGER4PTGER3 | |
| SCHEMBL8323432 | 0.71 | PTGER1 (0.57) | PTGER1HTR1ADRD2ADRB1ADRB3 | |
| SCHEMBL8320635 | 0.69 | MEN1 (0.56) | PTGER1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL9058743 | 0.69 | PTGER1 (0.69) | PTGER1MEN1KMT2APTGER4PTGER3 | |
| SCHEMBL8319393 | 0.68 | PTGER1 (0.61) | PTGER1HTR1ADRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |