Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.68 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | CASP4 | P49662 | 1/20 | 0.60 |
| ▸ | CASP5 | P51878 | 1/20 | 0.60 |
| ▸ | CCR2 | P41597 | 1/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805498 | 1.00 | KDM4E (0.71) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL3143167 | 1.00 | KDM4E (0.71) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL2206628 | 0.98 | KDM4E (0.73) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL3156886 | 0.95 | KDM4E (0.73) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL4021524 | 0.85 | CXCR4 (0.65) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL20640309 | 0.85 | TRPV6 (0.62) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL9621043 | 0.84 | CXCR4 (0.67) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL23832519 | 0.84 | KDM4E (0.69) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL5626457 | 0.84 | ALDH1A1 (0.74) | KDM4EALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL7514453 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1LMNAMAPTKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736035-A4 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORP (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5847121-A | Production of nitro-benzyl-dota via direct peptide cyclization | NEORX CORPORATION (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0736035-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5541287-A | DIAGNOSIS USING CYCLIC TRIPEPTIDES WITH NITROBENZYL 1,4,7,10-TETRAAZACYCLODODECANE-N,N*,N**,N***TETRAACETIC ACID BIOTIN CONJUGATE FORMED BY ALKYLATION AND MULTISTAGE PROCESS | NEORX CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1995015335-A2 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1995-06-08 | — | — | WO | disclosed |
| EP-0296522-A2 | Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation | THE DOW CHEMICAL COMPANY (US) | 1988-12-28 | — | — | EP | disclosed |